Catalog: YM8635
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
SCD
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, IP, ELISA
MW
42kD (Calculated)
37kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
42kD
MW(Observed)
37kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0866R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
SCD
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Protein Name:
Acyl-CoA desaturase (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase)
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Background:
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015],
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Function:
Catalytic activity:Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.,cofactor:Iron.,Domain:The histidine box domains may contain the active site and/or be involved in metal ion binding.,Function:Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.,similarity:Belongs to the fatty acid desaturase family.,
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Cellular Localization:
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
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Tissue Expression:
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
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Research Areas:
>>Biosynthesis of unsaturated fatty acids ;
>>Metabolic pathways ;
>>Fatty acid metabolism ;
>>PPAR signaling pathway ;
>>AMPK signaling pathway ;
>>Alcoholic liver disease
>>Metabolic pathways ;
>>Fatty acid metabolism ;
>>PPAR signaling pathway ;
>>AMPK signaling pathway ;
>>Alcoholic liver disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM8635
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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