Catalog: YM8436
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
Main Information
Target
c-JUN
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
36kD (Calculated)
48kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Phospho-AP-1 (S63) Antibody detects endogenous levels of AP-1 protein only when phosphorylated at S63.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LTsPD
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
36kD
MW(Observed)
48kD
Modification
Phospho
Clonality
Monoclonal
Clone Number
PT0608R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Phospho-AP-1 (S63) Antibody detects endogenous levels of AP-1 protein only when phosphorylated at S63.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LTsPD
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Gene Name:
JUN
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Protein Name:
Transcription factor AP-1;jun;c-jun；AP-1
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Other Name:
JUN ;
Transcription factor AP-1 ;
Activator protein 1 ;
AP1 ;
Proto-oncogene c-Jun ;
V-jun avian sarcoma virus 17 oncogene homolog ;
p39
Transcription factor AP-1 ;
Activator protein 1 ;
AP1 ;
Proto-oncogene c-Jun ;
V-jun avian sarcoma virus 17 oncogene homolog ;
p39
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Database Link:
Background:
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008],
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Function:
Function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
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Reference Citation({{totalcount}})
Catalog: YM8436
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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