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Main Information
Target
SLC7A11
Host Species
Rabbit
Reactivity
Human, Mouse, Rat,
Applications
WB, IHC, IF, IP, ELISA
MW
55kD (Calculated)
37kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200,
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
55kD
MW(Observed)
37kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0398R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
SLC7A11
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Protein Name:
Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
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Other Name:
Cystine/glutamate transporter ;
Amino acid transport system xc- ;
Calcium channel blocker resistance protein CCBR1 ;
Solute carrier family 7 member 11 ;
xCT ;
Amino acid transport system xc- ;
Calcium channel blocker resistance protein CCBR1 ;
Solute carrier family 7 member 11 ;
xCT ;
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Background:
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
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Function:
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
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Cellular Localization:
Membrane
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Signaling Pathway
Reference Citation(2)
Gualou-Xiebai herb pair ameliorate atherosclerosis in HFD-induced ApoE−/− mice and inhibit the ox-LDL-induced injury of HUVECs by regulating the Nrf2-mediated ferroptosis
Journal：
JOURNAL OF ETHNOPHARMACOLOGY
Author：
Li Zhu
Year：
2024
Applications：
WB
Reactivity：
Human
Rutin targets AKT to inhibit ferroptosis in ventilator-induced lung injury
Journal：
PHYTOTHERAPY RESEARCH
Author：
Shengsong Chen
Year：
2024
Applications：
IHC
Reactivity：
Mouse
- 1
Catalog: YM8243
Size
Price
Status
Qty.
200μL
$600.00
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100μL
$340.00
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40μL
$190.00
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0
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