Catalog: YM3601
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
PPAR delta
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IF, IHC
MW
50kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IF 1:50-200; IHC 1:100-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
PPAR Delta protein detects endogenous levels of PPAR Delta
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
50kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
2F9
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Antigen&Target Information
Immunogen:
Recombinant Protein of PPAR Delta of PPAR Delta
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Specificity:
PPAR Delta protein detects endogenous levels of PPAR Delta
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Gene Name:
PPARD NR1C2 PPARB
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Protein Name:
PPAR Delta
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Other Name:
Peroxisome proliferator-activated receptor delta ;
PPAR-delta ;
NUCI ;
Nuclear hormone receptor 1 ;
NUC1 ;
Nuclear receptor subfamily 1 group C member 2 ;
Peroxisome proliferator-activated receptor beta ;
PPAR-beta ;
PPAR-delta ;
NUCI ;
Nuclear hormone receptor 1 ;
NUC1 ;
Nuclear receptor subfamily 1 group C member 2 ;
Peroxisome proliferator-activated receptor beta ;
PPAR-beta ;
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Background:
peroxisome proliferator activated receptor delta(PPARD) Homo sapiens This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
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Function:
Function:Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand.,online information:Peroxisome proliferator-activated receptor entry,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer with the retinoid X receptor.,tissue specificity:Ubiquitous with maximal levels in placenta and skeletal muscle.,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Research Areas:
>>PPAR signaling pathway ;
>>Wnt signaling pathway ;
>>Pathways in cancer ;
>>Acute myeloid leukemia
>>Wnt signaling pathway ;
>>Pathways in cancer ;
>>Acute myeloid leukemia
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM3601
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
Collect
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