Purified recombinant fragment of human NGFR p75 expressed in E. Coli.

NGFR p75 Monoclonal Antibody detects endogenous levels of NGFR p75 protein.

NGFR

Tumor necrosis factor receptor superfamily member 16

NGFR ;
TNFRSF16 ;
Tumor necrosis factor receptor superfamily member 16 ;
Gp80-LNGFR ;
Low affinity neurotrophin receptor p75NTR ;
Low-affinity nerve growth factor receptor ;
NGF receptor ;
p75 ICD ;
CD antigen CD271

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008],

Domain:Death domain is responsible for interaction with RANBP9.,Domain:The extracellular domain is responsible for interaction with NTRK1.,Function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1.,

Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine .

Brain,

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>PI3K-Akt signaling pathway ;
>>Apoptosis - multiple species ;
>>Neurotrophin signaling pathway ;
>>Transcriptional misregulation in cancer