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Main Information
Target
CD131
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
ELISA 1:5000-100000
Formulation
Phosphate-buffered solution
Source
Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Specificity
This recombinant monoclonal antibody can detects endogenous levels of CD131 protein.
Purification
Recombinant Expression and Affinity purified
Storage
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration
Please check the information on the tube
Modification
Unmodified
Clone Number
PN0625
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Antigen&Target Information
Immunogen:
Purified recombinant Human CD131
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Specificity:
This recombinant monoclonal antibody can detects endogenous levels of CD131 protein.
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Gene Name:
CSF2RB IL3RB IL5RB
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Protein Name:
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
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Other Name:
IL-3R common β chain ;
CDw131 ;
Beta-C antibody ;
CD131 antibody ;
CDw131 antibody ;
Colony stimulating factor 2 receptor beta antibody ;
Colony stimulating factor 2 receptor beta low affinity ;
granulocyte macrophage ;
antibody ;
Common beta chain antibody ;
Csf2rb antibody ;
Cytokine receptor common beta chain antibody ;
Cytokine receptor common beta chain precursor ;
CDw131 antigen ;
antibody ;
Cytokine receptor common subunit beta antibody ;
GM CSF/IL 3/IL 5 receptor common beta chain antibody ;
GM-CSF/IL-3/IL-5 receptor common beta subunit antibody ;
granulocyte-macrophage colony-stimulating factor receptor ;
beta antibody ;
IL3RB antibody ;
IL3RB_HUMAN antibody ;
IL5RB antibody ;
Interleukin 3 receptor ;
beta antibody ;
Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta ;
high affinity ;
antibody ;
Interleukin 5 receptor ;
beta antibody ;
SMDP5 antibody ;
stimulating factor 3 receptor ;
beta ;
high affinity ;
antibody ;
CDw131 ;
Beta-C antibody ;
CD131 antibody ;
CDw131 antibody ;
Colony stimulating factor 2 receptor beta antibody ;
Colony stimulating factor 2 receptor beta low affinity ;
granulocyte macrophage ;
antibody ;
Common beta chain antibody ;
Csf2rb antibody ;
Cytokine receptor common beta chain antibody ;
Cytokine receptor common beta chain precursor ;
CDw131 antigen ;
antibody ;
Cytokine receptor common subunit beta antibody ;
GM CSF/IL 3/IL 5 receptor common beta chain antibody ;
GM-CSF/IL-3/IL-5 receptor common beta subunit antibody ;
granulocyte-macrophage colony-stimulating factor receptor ;
beta antibody ;
IL3RB antibody ;
IL3RB_HUMAN antibody ;
IL5RB antibody ;
Interleukin 3 receptor ;
beta antibody ;
Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta ;
high affinity ;
antibody ;
Interleukin 5 receptor ;
beta antibody ;
SMDP5 antibody ;
stimulating factor 3 receptor ;
beta ;
high affinity ;
antibody ;
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Background:
CD131, also known as the IL-3R common β subunit , is a 95-120 kD type I transmembrane glycoprotein and belongs to the Ig superfamily. The common β subunit associates with the specific α subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response. The 1C1 antibody is a non-blocking antibody.
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Function:
Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124).
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Cellular Localization:
Membrane; Single-pass type I membrane protein.
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Tissue Expression:
Blood,PCR rescued clones
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Signaling Pathway
Organismal Systems >> Immune system >> Hematopoietic cell lineage Organismal Systems >> Immune system >> T cell receptor signaling pathway Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation Organismal Systems >> Immune system >> Th17 cell differentiation Organismal Systems >> Immune system >> IL-17 signaling pathway Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway Organismal Systems >> Immune system >> Intestinal immune network for IgA production Human Diseases >> Cancer: overview >> Pathways in cancer Human Diseases >> Immune disease >> Asthma Human Diseases >> Immune disease >> Autoimmune thyroid disease Human Diseases >> Immune disease >> Inflammatory bowel disease Human Diseases >> Immune disease >> Allograft rejection Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Catalog: YA0621
Size
Price
Status
Qty.
200μg
$600.00
3 weeks
0
100μg
$340.00
3 weeks
0
40μg
$190.00
3 weeks
0
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