Purified recombinant Human CD54

This recombinant monoclonal antibody can detects endogenous levels of CD54 protein.

ICAM1

Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)

Antigen identified by monoclonal antibody BB2 antibody ;
BB 2 antibody ;
BB2 antibody ;
CD 54 antibody ;
CD_antigen=CD54 antibody ;
CD54 antibody ;
Cell surface glycoprotein P3.58 antibody ;
Human rhinovirus receptor antibody ;
ICAM 1 antibody ;
ICAM-1 antibody ;
ICAM1 antibody ;
ICAM1_HUMAN antibody ;
intercellular adhesion molecule 1 ;
CD54 ;
antibody ;
intercellular adhesion molecule 1 ;
CD54 ;
human rhinovirus receptor antibody ;
Intercellular adhesion molecule 1 antibody ;
Major group rhinovirus receptor antibody ;
MALA 2 antibody ;
MALA2 antibody ;
MyD 10 antibody ;
MyD10 antibody ;
P3.58 antibody ;
Surface antigen of activated B cells antibody ;
Surface antigen of activated B cells ;
BB2 antibody ;
CD54 nanobody ;

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.,

Membrane; Single-pass type I membrane protein.

Detected on umbilical veil endothelial cells (PubMed:162579). Detected in placenta (at protein level) (PubMed:169283). Detected on endothelial cells (PubMed:169283).