CREB1

Cyclic AMP-responsive element-binding protein 1 ;
CREB-1 ;
cAMP-responsive element-binding protein 1 ;

disease:A chromosomal aberration involving CREB1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t (2;22) (q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type. ,function:This protein binds the cAMP response element (CRE) , a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity. ,PTM:Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity) . Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the bZIP family. ,similarity:Contains 1 bZIP domain. ,similarity:Contains 1 KID (kinase-inducible) domain. ,subunit:Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts , through the bZIP domain , with the coactivators TORC1/CRTC1 , TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133 , binds CREBBP. ,

cell morphogenesis , cell morphogenesis involved in differentiation , regulation of cytokine production , positive regulation of cytokine production , transcription , transcription , DNA-dependent , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , protein amino acid phosphorylation ,phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , axonogenesis , lactation , regulation of cell size ,positive regulation of biosynthetic process , response to organic substance , regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , regulation of cell death , phosphorylation , diencephalon development , pituitary gland development , cell projection organization , neuron differentiation , mammary gland development , forebrain development , neuron projection development , positive regulation of cellular biosynthetic process , multicellular organism reproduction , regulation of cellular component size , regulation of gene-specific transcription , RNA biosynthetic process , regulation of transforming growth factor-beta3 production , positive regulation of transforming growth factor-beta3 production , cellular component morphogenesis , cell part morphogenesis , endocrine system development , regulation of growth , regulation of multicellular organism growth , positive regulation of multicellular organism growth , response to drug , regulation of circadian rhythm , regulation of apoptosis , regulation of programmed cell death , positive regulation of gene-specific transcription , regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of growth , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , regulation of hormone secretion , positive regulation of hormone secretion , reproductive process in a multicellular organism , neuron development , cell morphogenesis involved in neuron differentiation , gland development , neuron projection morphogenesis , cell projection morphogenesis , regulation of secretion , positive regulation of secretion , positive regulation of transport , positive regulation of nitrogen compound metabolic process ,positive regulation of multicellular organismal process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of cellular localization ,

Nucleus .