Catalog: YM9570
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
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Collected
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Main Information
Target
ALDOA
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
39kD (Calculated)
39kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
39kD
MW(Observed)
39kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT1728R
Isotype
IgG, Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
ALDOA
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Protein Name:
Fructose-bisphosphate aldolase A
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Other Name:
ALDOA ;
ALDA ;
Fructose-bisphosphate aldolase A ;
Lung cancer antigen NY-LU-1 ;
Muscle-type aldolase
ALDA ;
Fructose-bisphosphate aldolase A ;
Lung cancer antigen NY-LU-1 ;
Muscle-type aldolase
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Database Link:
Background:
The protein encoded by this gene , Aldolase A (fructose-bisphosphate aldolase) , is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1 ,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A , B , and C) , encoded by three different genes , are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver , kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq , Aug 2011] ,
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Function:
Catalytic activity:D-fructose 1 ,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. ,Disease:Defects in ALDOA are the cause of aldolase A deficiency [MIM:611881]; also known as aldoA deficiency or red cell aldolase deficiency. Aldolase A deficiency is an autosomal recessive disorder associated with hereditary hemolytic anemia. ,miscellaneous:In vertebrates , three forms of this ubiquitous glycolytic enzyme are found , aldolase A in muscle , aldolase B in liver and aldolase C in brain. ,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. ,similarity:Belongs to the class I fructose-bisphosphate aldolase family. ,subunit:Homotetramer. ,
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Cellular Localization:
Cytoplasm , myofibril , sarcomere , I band . Cytoplasm , myofibril , sarcomere , M line . In skeletal muscle , accumulates around the M line and within the I band , colocalizing with FBP2 on both sides of the Z line in the absence of Ca (2+) . .
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Tissue Expression:
Research Areas:
>>Glycolysis / Gluconeogenesis ;
>>Pentose phosphate pathway ;
>>Fructose and mannose metabolism ;
>>Metabolic pathways ;
>>Carbon metabolism ;
>>Biosynthesis of amino acids ;
>>HIF-1 signaling pathway
>>Pentose phosphate pathway ;
>>Fructose and mannose metabolism ;
>>Metabolic pathways ;
>>Carbon metabolism ;
>>Biosynthesis of amino acids ;
>>HIF-1 signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM9570
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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