Synthesized peptide derived from human protein . at AA range: 190-270

WNT4 Polyclonal Antibody detects endogenous levels of protein.

WNT4 UNQ426/PRO864

Protein Wnt-4

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSe

Disease:Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]; also called Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls.,Disease:Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]; also known as SERKAL syndrome.,Function:Ligand for members of the frizzled family of seven transmembrane receptors.,Function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN.,

Secreted, extracellular space, extracellular matrix.

>>mTOR signaling pathway ;
>>Wnt signaling pathway ;
>>Axon guidance ;
>>Hippo signaling pathway ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Melanogenesis ;
>>Thyroid hormone signaling pathway ;
>>Cushing syndrome ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Human papillomavirus infection ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Basal cell carcinoma ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer