Catalog: YM960297
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
TGIF
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IF, IP, ELISA
MW
43kD (Calculated)
32-34kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
43kD
MW(Observed)
32-34kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT2033R
Isotype
IgG, Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
TGIF1
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Protein Name:
Homeobox protein TGIF1
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Other Name:
TGIF1 ;
TGIF ;
Homeobox protein TGIF1 ;
5'-TG-3'-interacting factor 1
TGIF ;
Homeobox protein TGIF1 ;
5'-TG-3'-interacting factor 1
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Background:
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element , the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4 , which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provide
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Function:
Disease:Defects in TGIF1 are the cause of holoprosencephaly type 4 (HPE4) [MIM:142946]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain , in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. ,Function:Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE) . Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult , as illustrated by the down-modulation of the RXR alpha activities. ,similarity:Belongs to the TALE/TGIF homeobox family. ,similarity:Contains 1 homeobox DNA-binding domain. ,subunit:Interacts with CTBP , SMAD2 , SMAD3 and HDAC1. ,
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Cellular Localization:
Nucleus.
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Tissue Expression:
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Research Areas:
>>TGF-beta signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM960297
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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