Endogenous

MTOR

Serine/threonine-protein kinase mTOR

MTOR ;
FRAP ;
FRAP1 ;
FRAP2 ;
RAFT1 ;
RAPT1 ;
Serine/threonine-protein kinase mTOR ;
FK506-binding protein 12-rapamycin complex-associated protein 1 ;
FKBP12-rapamycin complex-associated protein ;
Mammalian target of rapamycin ;
mTOR ;
Mechanistic tar

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008],

Function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 FAT domain.,similarity:Contains 1 FATC domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 7 HEAT repeats.,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.,tissue specificity:Expressed in numerous tissues, with highest levels in testis.,

Cytoplasm

Expressed in numerous tissues, with highest levels in testis.

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>ErbB signaling pathway ;
>>HIF-1 signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Autophagy - other ;
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Cellular senescence ;
>>Apelin signaling pathway ;
>>Neutrophil extracellular trap formation ;
>>JAK-STAT signaling pathway ;
>>Th17 cell differentiation ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Adipocytokine signaling pathway ;
>>Type II diabetes mellitus ;
>>Insulin resistance ;
>>Growth hormone synthesis, secretion and action ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Colorectal cancer ;
>>Pancreatic cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Acute myeloid leukemia ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer ;
>>Central carbon metabolism in cancer ;
>>Choline metabolism in cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Diabetic cardiomyopathy