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IL-15 recombinant protein

-YD3051

Catalog: YD3051
Size
Price
Status
Qty.
500μg
$1,356.00
3 weeks

0

50μg
$272.00
3 weeks

0

5μg
$52.00
3 weeks

0

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Main Information
Reactivity

Human,

Detailed Information
Formulation
Phosphate-buffered solution
Source
Mammalian cells
Purity
>90% as determined by SDS-PAGE
Storage
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Antigen&Target Information
Gene Name:
IL15
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Protein Name:
Interleukin-15 (IL-15)
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Other Name:
Interleukin-15 ;
IL-15 ;
IL15 ;
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Database Link:
Organism Gene ID SwissProt
Human 3600; P40933;
Function:
Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770). Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8178155, PubMed:9326248). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (PubMed:9326248). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits (PubMed:10233906, PubMed:23104097, PubMed:8026467). Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (PubMed:7568001). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
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Cellular Localization:
[Isoform IL15-S48AA]: Secreted.; [Isoform IL15-S21AA]: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
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Tissue Expression:
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
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Catalog: YD3051
Size
Price
Status
Qty.
500μg
$1,356.00
3 weeks

0

50μg
$272.00
3 weeks

0

5μg
$52.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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