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IFNG recombinant protein

-YD3049

Catalog: YD3049
Size
Price
Status
Qty.
500μg
$1,356.00
3 weeks

0

50μg
$272.00
3 weeks

0

5μg
$52.00
3 weeks

0

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Collected

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Main Information
Reactivity

Human,

Detailed Information
Formulation
Phosphate-buffered solution
Source
Mammalian cells
Purity
>90% as determined by SDS-PAGE
Storage
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Antigen&Target Information
Sequence:
Amino acid:24-166,with human FC tag.
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Gene Name:
IFNG
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Protein Name:
Interferon gamma (IFN-gamma) (Immune interferon)
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Other Name:
Interferon gamma ;
IFN-gamma ;
Immune interferon ;
IFNG ;
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Database Link:
Organism Gene ID SwissProt
Human 3458; P01579;
Function:
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMed:8666937). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation (PubMed:8349687). Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription (PubMed:16914093). Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits (PubMed:8666937). In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading (PubMed:8163024). Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference (PubMed:11112687). Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (PubMed:7729559). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
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Cellular Localization:
Secreted.
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Tissue Expression:
Released primarily from activated T lymphocytes.
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Signaling Pathway
Catalog: YD3049
Size
Price
Status
Qty.
500μg
$1,356.00
3 weeks

0

50μg
$272.00
3 weeks

0

5μg
$52.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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