Catalog: KA3034C
Size
Price
Status
Qty.
96well
$330.00
2 weeks
0
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
Unmodified
Detection Method
Colorimetric
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KA3034C
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Antigen&Target Information
Gene Name:
ATF4
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Other Name:
ATF4 ;
CREB2 ;
TXREB ;
Cyclic AMP-dependent transcription factor ATF-4 ;
cAMP-dependent transcription factor ATF-4 ;
Activating transcription factor 4 ;
Cyclic AMP-responsive element-binding protein 2 ;
CREB-2 ;
cAMP-responsive element-binding prot
CREB2 ;
TXREB ;
Cyclic AMP-dependent transcription factor ATF-4 ;
cAMP-dependent transcription factor ATF-4 ;
Activating transcription factor 4 ;
Cyclic AMP-responsive element-binding protein 2 ;
CREB-2 ;
cAMP-responsive element-binding prot
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Background:
function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') , a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. ,similarity:Belongs to the bZIP family. ,similarity:Contains 1 bZIP domain. ,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. ,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity) . Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290. ,
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Function:
monosaccharide metabolic process , glucose metabolic process , pyruvate metabolic process , gluconeogenesis ,transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter ,positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , carbohydrate biosynthetic process , hexose metabolic process , hexose biosynthetic process , positive regulation of cellular biosynthetic process ,cellular response to stress , cellular carbohydrate biosynthetic process , response to endoplasmic reticulum stress ,regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , alcohol biosynthetic process , monosaccharide biosynthetic process ,positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process ,
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Cellular Localization:
Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity) . Colocalizes with NEK6 at the centrosome (PubMed:20873783) . Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772) . .
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Organismal Systems >> Endocrine system >> Insulin secretion
Organismal Systems >> Endocrine system >> Glucagon signaling pathway
Organismal Systems >> Endocrine system >> GnRH signaling pathway
Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Organismal Systems >> Endocrine system >> Relaxin signaling pathway
Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action
Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes
Organismal Systems >> Nervous system >> Cholinergic synapse
Organismal Systems >> Nervous system >> Dopaminergic synapse
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Organismal Systems >> Aging >> Longevity regulating pathway
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Parkinson disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Prion disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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Catalog: KA3034C
Size
Price
Status
Qty.
96well
$330.00
2 weeks
0
Add to cart
Collected
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