Catalog: KA1529C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
Related Products
Primary Antibodies
CRMP-2 Rabbit pAb
YT1115
More→
Primary Antibodies
CRMP-2 (Phospho Thr514) Rabbit pAb
YP0947
More→
Primary Antibodies
CRMP-2 (Phospho Thr509) Rabbit pAb
YP0814
More→
Primary Antibodies
CRMP-2 (Phospho Ser522) Rabbit pAb
YP0513
More→
ELISA Kits
Total CRMP-2 Cell-Based Colorimetric ELISA Kit
KA4057C
More→
ELISA Kits
CRMP-2 (Phospho Thr509) Cell-Based Colorimetric ELISA Kit
KA1746C
More→
ELISA Kits
CRMP-2 (Phospho Thr514) Cell-Based Colorimetric ELISA Kit
KA1529C
More→
Antigen&Target Information
Gene Name:
DPYSL2
show all
Other Name:
Dihydropyrimidinase-related protein 2 ;
DRP-2 ;
Collapsin response mediator protein 2 ;
CRMP-2 ;
N2A3 ;
Unc-33-like phosphoprotein 2 ;
ULIP-2 ;
DRP-2 ;
Collapsin response mediator protein 2 ;
CRMP-2 ;
N2A3 ;
Unc-33-like phosphoprotein 2 ;
ULIP-2 ;
show all
Database Link:
Background:
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance , growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse , and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders , and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq , Sep 2011] ,
show all
Function:
Function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance , neuronal growth cone collapse and cell migration. ,PTM:3F4 , a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains , specifically labels DPYSL2 when phosphorylated on Ser-518 , Ser-522 and Thr-509. ,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. ,subunit:Homotetramer , and heterotetramer with CRMP1 , DPYSL3 , DPYSL4 or DPYSL5 (By similarity) . Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. ,tissue specificity:Ubiquitous. ,
show all
Cellular Localization:
Cytoplasm , cytosol . Cytoplasm , cytoskeleton . Membrane . Tightly but non-covalently associated with membranes.
show all
Tissue Expression:
show all
Reference Citation({{totalcount}})
Catalog: KA1529C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}