RAD51

DNA repair protein RAD51 homolog 1 ;
HsRAD51 ;
hRAD51 ;
RAD51 homolog A ;

disease:Defects in RAD51 are associated with breast cancer (BC) [MIM:114480]. ,function:May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. ,PTM:Phosphorylated. Phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. ,similarity:Belongs to the recA family. ,similarity:Belongs to the recA family. RAD51 subfamily. ,similarity:Contains 1 HhH domain. ,subcellular location:Colocalizes with RAD51AP1 to multiple nuclear foci upon induction of DNA damage. ,subunit:Interacts with BRCA1 , BRCA2 and either directly or indirectly with p53. Interacts with XRCC3 , RAD54L and RAD54B. Part of a complex with RAD51C and RAD51B. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1/CHK1 , and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer (By similarity) . Interacts with OBFC2B. ,tissue specificity:Highly expressed in testis and thymus , followed by small intestine , placenta , colon , pancreas and ovary. Weakly expressed in breast. ,

M phase , double-strand break repair via homologous recombination , recombinational repair , DNA metabolic process ,DNA replication , DNA-dependent DNA replication , DNA unwinding during replication , DNA repair , double-strand break repair , DNA recombination , mitotic recombination , protein complex assembly , response to DNA damage stimulus , cell cycle , meiosis , meiosis I , reciprocal meiotic recombination , positive regulation of macromolecule metabolic process , cell cycle process , cell cycle phase , DNA geometric change , DNA duplex unwinding , cellular response to stress ,macromolecular complex subunit organization , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , regulation of DNA metabolic process , positive regulation of DNA metabolic process , regulation of DNA ligation , positive regulation of DNA ligation , positive regulation of nitrogen compound metabolic process ,protein oligomerization , protein homooligomerization , meiotic cell cycle , M phase of meiotic cell cycle , macromolecular complex assembly , protein complex biogenesis ,

Nucleus . Cytoplasm . Cytoplasm , perinuclear region. Mitochondrion matrix . Chromosome . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705) . DNA damage induces an increase in nuclear levels (PubMed:20154705) . Together with FIGNL1 , redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376) . Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288) . Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855) . Colocalizes with ERCC5/XPG to nuclear foci in S phase (PubMed:26833090) . .