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CD305 (LAIR1) recombinant protein

-YD3007

Catalog: YD3007
Size
Price
Status
Qty.
500μg
$1,356.00
3 weeks

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50μg
$272.00
3 weeks

0

5μg
$52.00
3 weeks

0

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Main Information
Reactivity

Human,

Detailed Information
Formulation
Phosphate-buffered solution
Source
Mammalian cells
Purity
>90% as determined by SDS-PAGE
Storage
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Antigen&Target Information
Sequence:
Amino acid:22-165,with human FC tag.
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Gene Name:
LAIR1
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Protein Name:
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)
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Other Name:
Leukocyte-associated immunoglobulin-like receptor 1 ;
LAIR-1 ;
hLAIR1 ;
CD antigen CD305 ;
LAIR1 ;
CD305 ;
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Database Link:
Organism Gene ID SwissProt
Human 3903; Q6GTX8;
Function:
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
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Tissue Expression:
Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.
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Catalog: YD3007
Size
Price
Status
Qty.
500μg
$1,356.00
3 weeks

0

50μg
$272.00
3 weeks

0

5μg
$52.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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