CDC16

CDC16 ;
ANAPC6 ;
Cell division cycle protein 16 homolog ;
Anaphase-promoting complex subunit 6 ;
APC6 ;
CDC16 homolog ;
CDC16Hs ;
Cyclosome subunit 6

function:Component of the anaphase promoting complex/cyclosome (APC/C) , a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. ,pathway:Protein modification; protein ubiquitination. ,PTM:Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis. ,similarity:Belongs to the APC6/CDC16 family. ,similarity:Contains 7 TPR repeats. ,subcellular location:Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle. ,subunit:The APC/C is composed of at least 11 subunits. Interacts with PPP5C and CDC20. ,

M phase of mitotic cell cycle , mitotic cell cycle , M phase , nuclear division , proteolysis , ubiquitin-dependent protein catabolic process , cell cycle , mitosis , regulation of mitosis , regulation of mitotic cell cycle , cell proliferation ,macromolecule catabolic process , proteasomal protein catabolic process , regulation of cell cycle process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , modification-dependent protein catabolic process , cell cycle process , cell cycle phase , protein catabolic process , anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process , regulation of protein ubiquitination , negative regulation of protein ubiquitination , positive regulation of protein ubiquitination , regulation of protein modification process , negative regulation of protein modification process , positive regulation of protein modification process , regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , regulation of organelle organization , positive regulation of catalytic activity , negative regulation of catalytic activity , proteasomal ubiquitin-dependent protein catabolic process , modification-dependent macromolecule catabolic process , negative regulation of molecular function ,positive regulation of molecular function , cellular protein catabolic process , cellular macromolecule catabolic process ,organelle fission , positive regulation of protein metabolic process , negative regulation of protein metabolic process ,cell division , regulation of ligase activity , positive regulation of ligase activity , negative regulation of ligase activity ,negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle , positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle , regulation of ubiquitin-protein ligase activity , regulation of ubiquitin-protein ligase activity during mitotic cell cycle , positive regulation of ubiquitin-protein ligase activity , negative regulation of ubiquitin-protein ligase activity , proteolysis involved in cellular protein catabolic process , regulation of cell cycle ,regulation of nuclear division ,

Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Cytoplasm , cytoskeleton , spindle . Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.