Catalog: KA1472C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
RFA2
show all
Other Name:
Replication protein A 32 kDa subunit ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34 ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34 ;
show all
Background:
function:Required for DNA recombination , repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. ,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis) . Phosphorylated by ATR upon DNA damage , which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA , and by CDC2. ,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage. ,subunit:Heterotrimer of 70 , 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN. ,
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Function:
nucleotide-excision repair , DNA damage removal , DNA metabolic process , DNA replication , DNA-dependent DNA replication , DNA repair , nucleotide-excision repair , nucleotide-excision repair , DNA gap filling , DNA catabolic process ,response to DNA damage stimulus , macromolecule catabolic process , cellular response to stress , cellular macromolecule catabolic process ,
show all
Cellular Localization:
Nucleus . Nucleus , PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .
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Reference Citation({{totalcount}})
Catalog: KA1472C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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