HDAC6

Histone deacetylase 6 ;
HD6 ;

catalytic activity:Hydrolysis of an N (6) -acetyl-lysine residue of a histone to yield a deacetylated histone. ,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A , H2B , H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation , cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) . Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. ,PTM:Sumoylated in vitro. ,PTM:Ubiquitinated. Its polyubiquitination however does not lead to its degradation. ,similarity:Belongs to the histone deacetylase family. Type 2 subfamily. ,similarity:Contains 1 UBP-type zinc finger. ,subcellular location:It is mainly cytoplasmic , where it is associated with microtubules. ,subunit:Interacts with CBFA2T3 , HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. ,

protein polyubiquitination , response to reactive oxygen species , chromatin organization , transcription , regulation of transcription , DNA-dependent , protein amino acid deacetylation , proteolysis , misfolded or incompletely synthesized protein catabolic process , intracellular protein transport , autophagy , response to oxidative stress , negative regulation of microtubule depolymerization , protein localization , macromolecule catabolic process , cellular response to starvation ,response to toxin , response to endogenous stimulus , positive regulation of biosynthetic process , positive regulation of signal transduction , response to extracellular stimulus , response to organic substance , response to inorganic substance , regulation of hydrogen peroxide metabolic process , regulation of receptor activity , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , regulation of epithelial cell migration , positive regulation of epithelial cell migration ,negative regulation of organelle organization , positive regulation of cell communication , negative regulation of oxygen and reactive oxygen species metabolic process , negative regulation of hydrogen peroxide metabolic process ,regulation of receptor biosynthetic process , positive regulation of receptor biosynthetic process , regulation of cell death , positive regulation of cell death , protein transport , macroautophagy , protein ubiquitination , chromatin modification , covalent chromatin modification , histone modification , histone deacetylation , peptidyl-lysine modification ,regulation of proteolysis , protein catabolic process , regulation of cell migration , positive regulation of cell migration ,regulation of microtubule polymerization or depolymerization , negative regulation of microtubule polymerization or depolymerization , regulation of microtubule depolymerization , positive regulation of protein complex assembly ,response to nutrient levels , cellular response to extracellular stimulus , cellular response to nutrient levels , regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , lysosome localization ,protein modification by small protein conjugation , regulation of microtubule-based process , regulation of organelle organization , regulation of steroid hormone receptor signaling pathway , cellular response to stress , cellular response to oxidative stress , cellular protein localization , cellular response to reactive oxygen species , peptidyl-lysine deacetylation , regulation of locomotion , positive regulation of locomotion , response to hydrogen peroxide , response to starvation , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of catalytic activity , negative regulation of protein complex disassembly , regulation of protein complex disassembly , regulation of protein complex assembly , regulation of cellular component biogenesis , negative regulation of molecular function , cellular protein catabolic process , cellular macromolecule catabolic process , establishment of protein localization , regulation of transcription , negative regulation of proteolysis , intracellular transport , negative regulation of cellular component organization , positive regulation of cellular component organization , negative regulation of protein metabolic process , regulation of RNA metabolic process , regulation of cell motion , positive regulation of cell motion , chromosome organization , regulation of oxidoreductase activity , negative regulation of oxidoreductase activity , regulation of cytoskeleton organization ,negative regulation of cytoskeleton organization , proteolysis involved in cellular protein catabolic process , organelle localization , response to misfolded protein , response to protein stimulus , regulation of microtubule-based movement ,regulation of androgen receptor signaling pathway , cellular response to hydrogen peroxide , regulation of microtubule cytoskeleton organization , protein modification by small protein conjugation or removal , cellular macromolecule localization , regulation of oxygen and reactive oxygen species metabolic process ,

Cytoplasm . Cytoplasm , cytoskeleton . Nucleus . Perikaryon . Cell projection , dendrite . Cell projection , axon . It is mainly cytoplasmic , where it is associated with microtubules. .