HDAC3

Histone deacetylase 3 ;
HD3 ;
RPD3-2 ;
SMAP45 ;

catalytic activity:Hydrolysis of an N (6) -acetyl-lysine residue of a histone to yield a deacetylated histone. ,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A , H2B , H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation , cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. ,PTM:Sumoylated in vitro. ,similarity:Belongs to the histone deacetylase family. Type 1 subfamily. ,subunit:Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX , HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex , at least composed of NCOR1 , NCOR2 , HDAC3 , TBL1X , TBL1R , CORO2A and GPS2. Interacts with BCOR , MJD2A/JHDM3A , NRIP1 , PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2 (By similarity) . Interacts with CBFA2T3. ,tissue specificity:Widely expressed. ,

negative regulation of transcription from RNA polymerase II promoter , microtubule cytoskeleton organization , M phase , angiogenesis , blood vessel development , liver development , vasculature development , chromatin organization ,transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter ,protein amino acid deacetylation , anti-apoptosis , cytoskeleton organization , microtubule-based process , cell cycle ,spindle organization , regulation of mitotic cell cycle , negative regulation of biosynthetic process , negative regulation of signal transduction , regulation of specific transcription from RNA polymerase II promoter , negative regulation of specific transcription from RNA polymerase II promoter , negative regulation of macromolecule biosynthetic process ,negative regulation of macromolecule metabolic process , regulation of protein kinase cascade , negative regulation of gene expression , negative regulation of cell communication , negative regulation of protein kinase cascade , regulation of myotube differentiation , negative regulation of myotube differentiation , regulation of cell death , regulation of striated muscle tissue development , negative regulation of transcription , chromatin modification , covalent chromatin modification , histone modification , histone deacetylation , cell cycle process , cell cycle phase , negative regulation of cellular biosynthetic process , negative regulation of gene-specific transcription , regulation of gene-specific transcription , response to drug , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , regulation of MAPKKK cascade , negative regulation of MAPKKK cascade , regulation of transcription , negative regulation of cell differentiation , negative regulation of cell cycle ,negative regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , regulation of JNK cascade , negative regulation of JNK cascade , blood vessel morphogenesis , negative regulation of response to stimulus , regulation of muscle development , regulation of skeletal muscle tissue development , regulation of skeletal muscle fiber development , regulation of muscle cell differentiation ,negative regulation of muscle cell differentiation , regulation of striated muscle cell differentiation , negative regulation of striated muscle cell differentiation , negative regulation of nitrogen compound metabolic process , spindle assembly ,regulation of RNA metabolic process , negative regulation of RNA metabolic process , chromosome organization ,regulation of cell cycle , regulation of cell development , negative regulation of cell death , regulation of stress-activated protein kinase signaling pathway , negative regulation of stress-activated protein kinase signaling pathway , regulation of cellular response to stress ,

Nucleus . Cytoplasm . Cytoplasm , cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803) . Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595) . .