GRK1

Rhodopsin kinase ;
RK ;
G protein-coupled receptor kinase 1 ;

catalytic activity:ATP + [rhodopsin] = ADP + [rhodopsin] phosphate. ,disease:Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation. ,function:Phosphorylates rhodopsin thereby initiating its deactivation. ,online information:Retina International's Scientific Newsletter ,PTM:Autophosphorylated. ,PTM:Farnesylation is required for full activity. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 RGS domain. ,tissue specificity:Retina and pineal gland. ,

cell morphogenesis , cell morphogenesis involved in differentiation , eye development , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , apoptosis , cell surface receptor linked signal transduction , G-protein coupled receptor protein signaling pathway , sensory organ development , sensory perception , visual perception , phototransduction , phototransduction , visible light , cell death , regulation of G-protein coupled receptor protein signaling pathway , photoreceptor cell morphogenesis , response to radiation , response to light stimulus , detection of external stimulus , detection of abiotic stimulus , detection of light stimulus , detection of visible light , rhodopsin mediated phototransduction , response to abiotic stimulus , post-embryonic development , post-embryonic morphogenesis , positive regulation of phosphorus metabolic process , programmed cell death , rhodopsin mediated signaling pathway , death , phosphorylation , regulation of phosphate metabolic process , neuron differentiation , cellular component morphogenesis , regulation of phosphorylation , positive regulation of phosphorylation , photoreceptor cell development , response to drug , camera-type eye development , positive regulation of phosphate metabolic process , photoreceptor cell differentiation , protein amino acid autophosphorylation ,eye morphogenesis , camera-type eye morphogenesis , neuron development , cell morphogenesis involved in neuron differentiation , neurological system process , cognition , detection of stimulus involved in sensory perception , detection of light stimulus involved in visual perception , sensory perception of light stimulus , detection of light stimulus involved in sensory perception , regulation of phosphorus metabolic process , detection of stimulus , retina development in camera-type eye , retina morphogenesis in camera-type eye , post-embryonic retina morphogenesis in camera-type eye ,

Membrane ; Lipid-anchor . Cell projection , cilium , photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. .