Catalog: KA1461C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
Related Products
Primary Antibodies
GluR4 Rabbit pAb
YT1924
More→
Primary Antibodies
GluR4 (Phospho Ser862) Rabbit pAb
YP0740
More→
ELISA Kits
Total GluR4 Cell-Based Colorimetric ELISA Kit
KA4107C
More→
ELISA Kits
GluR4 (Phospho Ser862) Cell-Based Colorimetric ELISA Kit
KA1461C
More→
Antigen&Target Information
Gene Name:
GRIA4
show all
Other Name:
Glutamate receptor 4 ;
GluR-4 ;
GluR4 ;
AMPA-selective glutamate receptor 4 ;
GluR-D ;
Glutamate receptor ionotropic,AMPA 4 ;
GluA4 ;
GluR-4 ;
GluR4 ;
AMPA-selective glutamate receptor 4 ;
GluR-D ;
Glutamate receptor ionotropic,AMPA 4 ;
GluA4 ;
show all
Database Link:
Background:
function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change , leading to the opening of the cation channel , and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state , characterized by the presence of bound agonist. ,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. ,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast , Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus. ,
show all
Function:
ion transport , cell surface receptor linked signal transduction , glutamate signaling pathway , cell-cell signaling , synaptic transmission , positive regulation of cell communication , transmission of nerve impulse , regulation of neurological system process , positive regulation of neurological system process , regulation of system process , regulation of synaptic transmission , positive regulation of synaptic transmission , neurological system process , positive regulation of multicellular organismal process , regulation of synaptic transmission , glutamatergic , positive regulation of synaptic transmission , glutamatergic , regulation of transmission of nerve impulse , positive regulation of transmission of nerve impulse ,
show all
Cellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction , synapse , postsynaptic cell membrane; Multi-pass membrane protein. Cell projection , dendrite. Interaction with CNIH2 , CNIH3 and PRKCG promotes cell surface expression. .
show all
Signaling Pathway
Organismal Systems >> Nervous system >> Glutamatergic synapse
Organismal Systems >> Nervous system >> Dopaminergic synapse
Human Diseases >> Neurodegenerative disease >> Huntington disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Reference Citation({{totalcount}})
Catalog: KA1461C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}