CTNND1

Catenin delta-1 ;
Cadherin-associated Src substrate ;
CAS ;
p120 catenin ;
p120 ;
ctn ;
p120 ;
cas ;

alternative products:Experimental confirmation may be lacking for some isoforms ,disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated. ,domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted. ,function:Binds to and inhibits the transcriptional repressor ZBTB33 , which may lead to activation of target genes of the Wnt signaling pathway (By similarity) . May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF , PDGF , CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. ,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress , which enhances wound closure. ,PTM:Phosphorylated. ,similarity:Belongs to the beta-catenin family. ,similarity:Contains 10 ARM repeats. ,subcellular location:Interaction with GLIS2 promotes nuclear translocation. ,subunit:Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin , alpha-catenin , beta-catenin , and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. ,tissue specificity:Expressed in vascular endothelium. ,

transcription , cell adhesion , cell surface receptor linked signal transduction , Wnt receptor signaling pathway , cell-cell adhesion , biological adhesion , regulation of transcription ,

Cell junction , adherens junction . Cytoplasm . Nucleus . Cell membrane . Interaction with GLIS2 promotes nuclear translocation (By similarity) . Detected at cell-cell contacts (PubMed:15240885 , PubMed:17047063) . NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063) . CDH1 enhances cell membrane localization (PubMed:15240885) . Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187) . .; [Isoform 1A]: Nucleus .; [Isoform 2A]: Nucleus .; [Isoform 3A]: Nucleus .