Catalog: KA1416C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Collected
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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YP0722
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ELISA Kits
Total PTP1B Cell-Based Colorimetric ELISA Kit
KA4257C
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ELISA Kits
PTP1B (Phospho Ser50) Cell-Based Colorimetric ELISA Kit
KA1416C
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Antigen&Target Information
Gene Name:
PTPN1
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Other Name:
Tyrosine-protein phosphatase non-receptor type 1 ;
Protein-tyrosine phosphatase 1B ;
PTP-1B ;
Protein-tyrosine phosphatase 1B ;
PTP-1B ;
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Database Link:
Background:
catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,function:May play an important role in CKII- and p60c-src-induced signal transduction cascades. ,PTM:Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link , triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. ,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. ,similarity:Contains 1 tyrosine-protein phosphatase domain. ,
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Function:
protein amino acid dephosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , insulin receptor signaling pathway , response to endogenous stimulus ,response to hormone stimulus , negative regulation of signal transduction , response to organic substance , negative regulation of cell communication , dephosphorylation , response to insulin stimulus , cellular response to insulin stimulus ,cellular response to hormone stimulus , response to peptide hormone stimulus , regulation of insulin receptor signaling pathway , negative regulation of insulin receptor signaling pathway , negative regulation of response to stimulus ,
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Cellular Localization:
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Interacts with EPHA3 at the cell membrane.
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Tissue Expression:
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: KA1416C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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