AHR

function:Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. ,induction:Induced or repressed by TGF-beta and dioxin in a cell-type specific fashion. Repressed by cAMP , retinoic acid , and TPA. ,similarity:Contains 1 basic helix-loop-helix (bHLH) domain. ,similarity:Contains 1 PAC (PAS-associated C-terminal) domain. ,similarity:Contains 2 PAS (PER-ARNT-SIM) domains. ,subcellular location:Initially cytoplasmic; upon binding with ligand and interaction with a HSP90 , it translocates to the nucleus. ,subunit:Binds MYBBP1A (By similarity) . Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus , heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1 , RIP140 and NOCA7 , and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. ,tissue specificity:Expressed in all tissues tested including blood , brain , heart , kidney , liver , lung , pancreas and skeletal muscle. ,

transcription , transcription , DNA-dependent , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , transcription from RNA polymerase II promoter , apoptosis , cell cycle , cell death ,response to xenobiotic stimulus , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression ,programmed cell death , death , positive regulation of cellular biosynthetic process , RNA biosynthetic process ,regulation of protein complex assembly , regulation of cellular component biogenesis , regulation of transcription ,positive regulation of transcription , DNA-dependent , regulation of transcriptional preinitiation complex assembly ,positive regulation of transcriptional preinitiation complex assembly , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , positive regulation of cellular component organization , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of transcription initiation from RNA polymerase II promoter ,

Cytoplasm . Nucleus . Initially cytoplasmic; upon binding with ligand and interaction with a HSP90 , it translocates to the nucleus. .