PRKCQ

Protein kinase C theta type ;
nPKC-theta ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,domain:The C1 domain , containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B) , is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain. ,enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain) , Ser-676 (turn motif) and Ser-695 (hydrophobic region) , need to be phosphorylated for its full activation. ,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters , a class of tumor promoters. ,function:This is a calcium-independent , phospholipid-dependent , serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR) -mediated T-cell activation , but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. ,PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 C2 domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers. ,subunit:Interacts with TXNL2/PICOT. ,tissue specificity:Skeletal muscle , megakaryoblastic cells and platelets. ,

regulation of cell growth , response to hypoxia , regulation of cytokine production , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , protein amino acid phosphorylation , proteolysis , membrane protein ectodomain proteolysis , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , regulation of mitotic cell cycle , aging , positive regulation of cell proliferation , macromolecule catabolic process , response to temperature stimulus , response to heat , response to wounding , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , response to carbohydrate stimulus , response to hexose stimulus , response to glucose stimulus , positive regulation of biosynthetic process , response to organic substance , regulation of G2/M transition of mitotic cell cycle , positive regulation of macromolecule biosynthetic process , regulation of cell cycle process , positive regulation of macromolecule metabolic process , positive regulation of organelle organization , response to organic cyclic substance ,phosphorylation , regulation of vasoconstriction , protein catabolic process , neuron differentiation , regeneration ,positive regulation of cellular biosynthetic process , regulation of cell projection organization , positive regulation of cell projection organization , regulation of actin filament bundle formation , positive regulation of actin filament bundle formation , regulation of intracellular transport , positive regulation of intracellular transport , regulation of interleukin-2 production , response to insulin stimulus , regulation of protein localization , regulation of mononuclear cell proliferation ,positive regulation of mononuclear cell proliferation , regulation of actin cytoskeleton organization , regulation of actin filament-based process , regulation of organelle organization , regulation of intracellular protein transport , membrane protein proteolysis , response to monosaccharide stimulus , growth , regulation of growth , regulation of cytokine biosynthetic process , wound healing , positive regulation of T cell proliferation , positive regulation of cytokine biosynthetic process , regulation of cell proliferation , regulation of T cell proliferation , tissue regeneration , regulation of protein import into nucleus , positive regulation of protein import into nucleus , regulation of NF-kappaB import into nucleus , positive regulation of NF-kappaB import into nucleus , regulation of transcription factor import into nucleus ,positive regulation of transcription factor import into nucleus , positive regulation of DNA binding , response to peptide hormone stimulus , regulation of system process , regulation of cellular component biogenesis , positive regulation of molecular function , cellular protein catabolic process , cellular macromolecule catabolic process , regulation of interleukin-2 biosynthetic process , positive regulation of interleukin-2 biosynthetic process , regulation of transcription ,respiratory burst , regulation of nucleocytoplasmic transport , positive regulation of nucleocytoplasmic transport ,developmental growth , regulation of lymphocyte proliferation , positive regulation of lymphocyte proliferation ,regulation of protein secretion , positive regulation of protein secretion , regulation of T cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of T cell activation , regulation of secretion , positive regulation of secretion , positive regulation of transport , regulation of transcription factor activity , positive regulation of transcription factor activity , positive regulation of NF-kappaB transcription factor activity , regulation of binding , positive regulation of binding , regulation of DNA binding , positive regulation of cellular component organization , positive regulation of protein transport , regulation of protein transport , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of filopodium assembly , positive regulation of filopodium assembly , regulation of stress fiber formation , regulation of cytoskeleton organization , positive regulation of cytoskeleton organization ,positive regulation of stress fiber formation , proteolysis involved in cellular protein catabolic process , regulation of cell cycle , regulation of cellular localization , regulation of cell projection assembly , regulation of establishment of protein localization , response to oxygen levels , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation ,

Cytoplasm. Cell membrane; Peripheral membrane protein. In resting T-cells , mostly localized in cytoplasm. In response to TCR stimulation , associates with lipid rafts and then localizes in the immunological synapse.