PIM1

Serine/threonine-protein kinase pim-1 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Manganese. ,function:Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. ,induction:Strongly induced in leukocytes by the JAK/STAT pathway in response to cytokines. ,PTM:Autophosphorylated on both serine/threonine and tyrosine residues. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds to RP9. Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Isoform 1 , but not isoform 2 , binds BMX. ,tissue specificity:Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. ,

regulation of cyclin-dependent protein kinase activity , G1/S transition of mitotic cell cycle , mitotic cell cycle , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell cycle , cell proliferation ,regulation of cell death , phosphorylation , regulation of phosphate metabolic process , cell cycle process , cell cycle phase , regulation of cyclin-dependent protein kinase activity during G1/S , positive regulation of cyclin-dependent protein kinase activity during G1/S , positive regulation of kinase activity , regulation of phosphorylation , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , negative regulation of DNA binding , negative regulation of transcription factor activity , regulation of kinase activity , negative regulation of molecular function , positive regulation of molecular function , regulation of transcription , positive regulation of cyclin-dependent protein kinase activity ,positive regulation of cell cycle , regulation of protein kinase activity , positive regulation of protein kinase activity ,protein amino acid autophosphorylation , regulation of transcription factor activity , regulation of binding , negative regulation of binding , regulation of DNA binding , regulation of phosphorus metabolic process , interphase , interphase of mitotic cell cycle , regulation of transferase activity , positive regulation of transferase activity , regulation of cell cycle ,negative regulation of cell death ,

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.