Catalog: KA1383C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Collected
Collect
Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Primary Antibodies
PEA-15 (Phospho Ser116) Rabbit pAb
YP0669
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ELISA Kits
Total PEA-15 Cell-Based Colorimetric ELISA Kit
KA4228C
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ELISA Kits
PEA-15 (Phospho Ser104) Cell-Based Colorimetric ELISA Kit
KA1383C
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ELISA Kits
PEA-15 (Phospho Ser116) Cell-Based Colorimetric ELISA Kit
KA1320C
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Antigen&Target Information
Gene Name:
PEA15
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Other Name:
Astrocytic phosphoprotein PEA-15 ;
15 kDa phosphoprotein enriched in astrocytes ;
Phosphoprotein enriched in diabetes ;
PED ;
15 kDa phosphoprotein enriched in astrocytes ;
Phosphoprotein enriched in diabetes ;
PED ;
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Database Link:
Background:
function:Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity) . Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. ,PTM:Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. ,similarity:Contains 1 DED (death effector) domain. ,subcellular location:Associated with microtubules. ,subunit:Binds RPS6KA3 , MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity) . Interacts with CASP8 and FADD. ,tissue specificity:Ubiquitously expressed. Most abundant in tissues such as heart , brain , muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. ,
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Function:
apoptosis , anti-apoptosis , cell death , carbohydrate transport , regulation of glucose transport , negative regulation of glucose transport , regulation of cell death , programmed cell death , death , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , regulation of glucose import , negative regulation of glucose import , negative regulation of transport , negative regulation of cell death ,
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Cellular Localization:
Cytoplasm. Associated with microtubules.
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Catalog: KA1383C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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