Catalog: KA1369C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
MAPKAPK2
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Other Name:
MAP kinase-activated protein kinase 2 ;
MAPK-activated protein kinase 2 ;
MAPKAP kinase 2 ;
MAPKAP-K2 ;
MAPKAPK-2 ;
MK-2 ;
MK2 ;
MAPK-activated protein kinase 2 ;
MAPKAP kinase 2 ;
MAPKAP-K2 ;
MAPKAPK-2 ;
MK-2 ;
MK2 ;
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Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Seems to be activated by two distinct pathways: the first involves the stimulation of p42/p44 MAPK by growth factors , the second , triggered by stress and heat shock , depends on the activation of MPK2 and upstream MAPKK/MAPKKK. ,function:Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25) . In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40') . This kinase phosphorylates Ser in the peptide sequence , Hyd-X-R-X (2) -S , where Hyd is a large hydrophobic residue (By similarity) . Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity. ,PTM:Phosphorylated and activated by MAP kinase. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with PHC2. ,tissue specificity:Expressed in all tissues examined. ,
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Function:
MAPKKK cascade , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process ,intracellular signaling cascade , protein kinase cascade , small GTPase mediated signal transduction , Ras protein signal transduction , posttranscriptional regulation of gene expression , mRNA metabolic process , phosphorylation , regulation of RNA stability , regulation of mRNA stability , RNA stabilization , mRNA stabilization , regulation of RNA metabolic process ,
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Cellular Localization:
Cytoplasm . Nucleus . Phosphorylation and subsequent activation releases the autoinhibitory helix , resulting in the export from the nucleus into the cytoplasm.
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Tissue Expression:
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Cellular senescence
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> VEGF signaling pathway
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Catalog: KA1369C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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