CCNB1 CCNB

CCNB1 ;
CCNB ;
G2/mitotic-specific cyclin-B1

developmental stage:Accumulates steadily during G2 and is abruptly destroyed at mitosis. ,function:Essential for the control of the cell cycle at the G2/M (mitosis) transition. ,PTM:Ubiquitinated by the SCF (NIPA) complex during interphase , leading to its destruction. Not ubiquitinated during G2/M phases. ,similarity:Belongs to the cyclin family. ,similarity:Belongs to the cyclin family. Cyclin AB subfamily. ,subunit:Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF) . The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. ,

G2/M transition of mitotic cell cycle , M phase of mitotic cell cycle , mitotic cell cycle , M phase , nuclear division , oocyte maturation , reproductive developmental process , proteolysis , ubiquitin-dependent protein catabolic process , cell cycle ,mitosis , gamete generation , germ cell development , female gamete generation , macromolecule catabolic process ,response to wounding , oocyte differentiation , proteasomal protein catabolic process , positive regulation of macromolecule metabolic process , modification-dependent protein catabolic process , sexual reproduction ,developmental maturation , cell cycle process , cell cycle phase , protein catabolic process , regeneration , anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process , regulation of protein ubiquitination , positive regulation of protein ubiquitination , regulation of protein modification process , positive regulation of protein modification process , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , multicellular organism reproduction , growth , wound healing , tissue regeneration ,positive regulation of catalytic activity , proteasomal ubiquitin-dependent protein catabolic process , modification-dependent macromolecule catabolic process , positive regulation of molecular function , cellular protein catabolic process , cellular macromolecule catabolic process , organelle fission , cell maturation , oogenesis , developmental growth , oocyte development , reproductive process in a multicellular organism , reproductive cellular process , positive regulation of protein metabolic process , cell division , interphase , interphase of mitotic cell cycle , regulation of ligase activity , positive regulation of ligase activity , positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle , regulation of ubiquitin-protein ligase activity , regulation of ubiquitin-protein ligase activity during mitotic cell cycle , positive regulation of ubiquitin-protein ligase activity , proteolysis involved in cellular protein catabolic process ,regulation of cell cycle ,

Cytoplasm. Nucleus. Cytoplasm , cytoskeleton , microtubule organizing center , centrosome.