SF1

Splicing factor 1 ;
Mammalian branch point-binding protein ;
BBP ;
mBBP ;
Transcription factor ZFM1 ;
Zinc finger gene in MEN1 locus ;
Zinc finger protein 162 ;

alternative products:Additional isoforms seem to exist ,function:Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. ,PTM:Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463. ,similarity:Belongs to the BBP/SF1 family. ,similarity:Contains 1 CCHC-type zinc finger. ,similarity:Contains 1 KH domain. ,subunit:Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1 , FUS and TAF15. ,tissue specificity:Detected in lung , ovary , adrenal gland , colon , kidney , muscle , pancreas , thyroid , placenta , brain , liver and heart. ,

spliceosome assembly , RNA splicing , via transesterification reactions , RNA splicing , via transesterification reactions with bulged adenosine as nucleophile , nuclear mRNA 3'-splice site recognition , nuclear mRNA splicing , via spliceosome ,reproductive developmental process , transcription , mRNA splice site selection , RNA processing , mRNA processing , cell cycle , sex determination , sex differentiation , negative regulation of cell proliferation , RNA splicing , gonad development ,male gonad development , mRNA metabolic process , regulation of lipid metabolic process , regulation of steroid metabolic process , cell cycle process , ribonucleoprotein complex biogenesis , ribonucleoprotein complex assembly , male sex determination , Leydig cell differentiation , cellular macromolecular complex subunit organization , cellular macromolecular complex assembly , regulation of cell proliferation , macromolecular complex subunit organization ,development of primary sexual characteristics , regulation of transcription , development of primary male sexual characteristics , male sex differentiation , regulation of lipid biosynthetic process , reproductive structure development ,reproductive cellular process , regulation of smooth muscle cell proliferation , negative regulation of smooth muscle cell proliferation , regulation of steroid biosynthetic process , macromolecular complex assembly ,

Nucleus.