Catalog: KA1596C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Primary Antibodies
JAK1 Rabbit pAb
YT2424
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Primary Antibodies
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YP0154
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Primary Antibodies
JAK1 (7G6) Mouse mAb
YM3606
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ELISA Kits
JAK1 (Phospho Tyr1022) Cell-Based Colorimetric ELISA Kit
KA1596C
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Antigen&Target Information
Gene Name:
JAK1
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Other Name:
Tyrosine-protein kinase JAK1 ;
Janus kinase 1 ;
JAK-1 ;
Janus kinase 1 ;
JAK-1 ;
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Background:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity) , while the presence of slight differences suggest a different role for domain 1. ,domain:The FERM domain mediates interaction with JAKMIP1. ,function:Tyrosine kinase of the non-receptor type , involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL) -2 receptor. ,sequence caution:Translation N-terminally extended. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. ,similarity:Contains 1 FERM domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,subcellular location:Wholly intracellular , possibly membrane associated. ,subunit:Interacts with IL31RA , JAKMIP1 and SHB. ,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. ,
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Function:
protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , intracellular signaling cascade ,protein kinase cascade , phosphorylation , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , cytokine-mediated signaling pathway , response to antibiotic ,
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Cellular Localization:
Endomembrane system; Peripheral membrane protein. Wholly intracellular , possibly membrane associated.
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Necroptosis
Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation
Organismal Systems >> Immune system >> Th17 cell differentiation
Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
Human Diseases >> Cancer: specific types >> Pancreatic cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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Catalog: KA1596C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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