Catalog: IHCM6111
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100mL
$2,960.00
3 weeks
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10mL
$356.00
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3mL
$156.00
3 weeks
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Main Information
Target
BOB.1
Host Species
Mouse
Reactivity
Human, Mouse,
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Specificity
The antibody can specifically recognize human BOB.1 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-BOB1
Isotype
IgG2a,Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human BOB.1 AA range: 150-256
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Specificity:
The antibody can specifically recognize human BOB.1 protein.
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Gene Name:
POU2AF1 OBF1
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Protein Name:
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
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Other Name:
POU domain class 2-associating factor 1 ;
B-cell-specific coactivator OBF-1 ;
BOB-1 ;
OCA-B ;
OCT-binding factor 1 ;
B-cell-specific coactivator OBF-1 ;
BOB-1 ;
OCA-B ;
OCT-binding factor 1 ;
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Background:
BOB.1 is a transcription activating factor necessary for the formation of follicular germinal center and the production of immunoglobulin. It works together with Oct-2 and is highly expressed in granulocytes of spleen and peripheral blood. It is mainly used for the typing of Hodgkin's lymphoma, mainly nodular lymphocytes. Hodgkin's lymphoma is positive and classical Hodgkin's lymphoma is negative.
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Function:
Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,Function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,
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Cellular Localization:
Nuclear, Cytoplasmic
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Tissue Expression:
B-cell specific (PubMed:7779176, PubMed:7859290). Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine (PubMed:7779176, PubMed:7859290).
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Reference Citation({{totalcount}})
Catalog: IHCM6111
Size
Price
Status
Qty.
100mL
$2,960.00
3 weeks
0
10mL
$356.00
3 weeks
0
3mL
$156.00
3 weeks
0
Add to cart
Collected
Collect
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