GRIN2B

Glutamate [NMDA] receptor subunit epsilon-2 ;
N-methyl D-aspartate receptor subtype 2B ;
NMDAR2B ;
NR2B ;
N-methyl-D-aspartate receptor subunit 3 ;
NR3 ;
hNR3 ;

function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subunit:Forms heteromeric channel of a zeta subunit (GRIN1) , a epsilon subunit (GRIN2A , GRIN2B , GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B) . Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1 , GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 (By similarity) . Interacts with MAGI3. ,tissue specificity:Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells , lower expression in the basal ganglia. ,

regulation of action potential , behavioral fear response , in utero embryonic development , startle response , suckling behavior , behavioral defense response , ion transport , cation transport , calcium ion transport , cellular ion homeostasis ,defense response , cell surface receptor linked signal transduction , glutamate signaling pathway , cell-cell signaling ,synaptic transmission , sensory organ development , sensory perception , behavior , learning or memory , learning ,memory , feeding behavior , associative learning , detection of external stimulus , detection of abiotic stimulus , response to mechanical stimulus , response to abiotic stimulus , embryonic development ending in birth or egg hatching ,response to organic substance , regulation of protein kinase cascade , regulation of glutamate secretion , positive regulation of glutamate secretion , di- , tri-valent inorganic cation transport , transmission of nerve impulse , sensory perception of pain , cellular homeostasis , metal ion transport , regulation of neurological system process , multicellular organismal response to stress , ionotropic glutamate receptor signaling pathway , regulation of membrane potential ,homeostatic process , fear response , chordate embryonic development , regulation of MAPKKK cascade , regulation of system process , response to ethanol , regulation of synaptic plasticity , regulation of neuronal synaptic plasticity ,regulation of long-term neuronal synaptic plasticity , response to pain , behavioral response to pain , rhythmic process ,chemical homeostasis , ion homeostasis , regulation of synaptic transmission , neurological system process , cognition ,neuromuscular process , detection of stimulus involved in sensory perception , sensory perception of mechanical stimulus , detection of mechanical stimulus involved in sensory perception of pain , detection of mechanical stimulus involved in sensory perception , detection of mechanical stimulus , regulation of secretion , positive regulation of secretion , positive regulation of transport , detection of stimulus , behavioral interaction between organisms ,membrane depolarization , regulation of transmission of nerve impulse , cellular chemical homeostasis , regulation of postsynaptic membrane potential , regulation of excitatory postsynaptic membrane potential , regulation of cellular localization ,

Cell membrane ; Multi-pass membrane protein . Cell junction , synapse , postsynaptic cell membrane ; Multi-pass membrane protein . Late endosome . Lysosome . Cytoplasm , cytoskeleton . Co-localizes with the motor protein KIF17 along microtubules. .