MET

Hepatocyte growth factor receptor ;
HGF receptor ;
HGF/SF receptor ;
Proto-oncogene c-Met ;
Scatter factor receptor ;
SF receptor ;
Tyrosine-protein kinase Met ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,disease:Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. ,disease:Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. ,disease:Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2) . HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple , bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. ,disease:Defects in MET may be associated with gastric cancer. ,disease:Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9) [MIM:611015]. Autism is a neurodevelopmental disorder characterized by disturbance in language , perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication , a lack of reciprocal social interaction or responsiveness , and restricted , stereotypical , and ritualized patterns of interests and behavior. ,domain:The kinase domain is involved in SPSB1 binding. ,function:Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation , scattering , morphogenesis and survival. ,online information:C-MET entry ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 Sema domain. ,similarity:Contains 3 IPT/TIG domains. ,subunit:Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1 , SPSB2 and SPSB4 (By similarity) . Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356 , interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10 , as well as SPSB1 , SPSB2 , SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF , however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. ,

MAPKKK cascade , activation of MAPK activity , neuron migration , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell motion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway ,intracellular signaling cascade , protein kinase cascade , muscle organ development , lactation , behavior , cell proliferation , phosphorylation , cell migration , regulation of phosphate metabolic process , sperm motility , adult behavior , mammary gland development , multicellular organism reproduction , positive regulation of kinase activity ,regulation of phosphorylation , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of kinase activity , positive regulation of molecular function , regulation of protein kinase activity , positive regulation of protein kinase activity , protein amino acid autophosphorylation ,hepatocyte growth factor receptor signaling pathway , reproductive process in a multicellular organism , gland development , cell motility , regulation of phosphorus metabolic process , regulation of transferase activity , positive regulation of transferase activity , myoblast proliferation , localization of cell ,

Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.