GRIA2 GLUR2

GRIA2 ;
GLUR2 ;
Glutamate receptor 2 ;
GluR-2 ;
AMPA-selective glutamate receptor 2 ;
GluR-B ;
GluR-K2 ;
Glutamate receptor ionotropic ;
AMPA 2 ;
GluA2

function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change , leading to the opening of the cation channel , and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state , characterized by the presence of bound agonist. ,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. ,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast , Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. ,RNA editing:Partially edited. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium , whereas the unedited (Q) forms are highly permeable to divalent ions. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PRKCABP , GRIP1 and GRIP2. ,

regulation of receptor recycling , ion transport , endocytosis , receptor-mediated endocytosis , cell-cell signaling , synaptic transmission , protein localization , response to inorganic substance , response to metal ion , response to lithium ion ,membrane invagination , positive regulation of cell communication , membrane organization , vesicle-mediated transport , transmission of nerve impulse , receptor internalization , regulation of neurological system process , positive regulation of neurological system process , receptor metabolic process , regulation of system process , establishment of protein localization , regulation of synaptic transmission , positive regulation of synaptic transmission , neurological system process , positive regulation of multicellular organismal process , regulation of synaptic transmission , glutamatergic , regulation of transmission of nerve impulse , positive regulation of transmission of nerve impulse ,

Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction , synapse , postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction , synapse , postsynaptic density membrane ; Multi-pass membrane protein . Interaction with CACNG2 , CNIH2 and CNIH3 promotes cell surface expression (By similarity) . Displays a somatodendritic localization and is excluded from axons in neurons (By similarity) . .