LAT

Linker for activation of T-cells family member 1 ;
36 kDa phospho-tyrosine adapter protein ;
pp36 ;
p36-38 ;

function:Required for TCR (T-cell antigen receptor) - and pre-TCR-mediated signaling , both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III) -mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores , PKC activation , MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1 , GRB2 , GRAP2 , and other signaling molecules. ,miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC , maybe by inducing the dephosphorylation of LAT. ,PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation. ,PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation , or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. ,subcellular location:Present in lipid rafts. ,subunit:When phosphorylated , interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2 , GRAP , GRAP2 , PLCG1 and PLCG2. Interacts indirectly with CBL , SOS , VAV , and LCP2. Interacts with SHB , SKAP2 and CLNK (By similarity) . Interacts with FCGR1A. ,tissue specificity:Expressed in thymus , T-cells , NK cells , mast cells and , at lower levels , in spleen. Present in T-cells but not B-cells (at protein level) . ,

cell activation , immune effector process , cell activation during immune response , myeloid leukocyte activation , myeloid cell activation during immune response , leukocyte activation during immune response , leukocyte mediated immunity ,myeloid leukocyte mediated immunity , mast cell mediated immunity , regulation of leukocyte activation , exocytosis ,immune response , cell surface receptor linked signal transduction , integrin-mediated signaling pathway , intracellular signaling cascade , small GTPase mediated signal transduction , Ras protein signal transduction , vesicle-mediated transport , calcium-mediated signaling , second-messenger-mediated signaling , secretion by cell , leukocyte degranulation , mast cell degranulation , regulated secretory pathway , leukocyte activation , mast cell activation ,secretion , regulation of T cell activation , regulation of cell activation , regulation of lymphocyte activation ,

Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.