ADRBK1 BARK BARK1 GRK2

ADRBK1 ;
BARK ;
BARK1 ;
GRK2 ;
Beta-adrenergic receptor kinase 1 ;
Beta-ARK-1 ;
G-protein coupled receptor kinase 2

catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate. ,catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors , probably inducing a desensitization of them. ,online information:Beta adrenergic receptor kinase entry ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 RGS domain. ,subunit:Interacts with GIT1 (By similarity) . Interacts with , and phosphorylates chemokine-stimulated CCR5. ,tissue specificity:Expressed in peripheral blood leukocytes. ,

response to reactive oxygen species , regulation of the force of heart contraction , desensitization of G-protein coupled receptor protein signaling pathway , muscle system process , circulatory system process , heart process , regulation of the force of heart contraction by chemical signal , negative regulation of the force of heart contraction by chemical signal , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , muscle contraction , regulation of muscle contraction , striated muscle contraction , regulation of striated muscle contraction ,response to oxidative stress , cell surface receptor linked signal transduction , G-protein coupled receptor protein signaling pathway , muscarinic acetylcholine receptor signaling pathway , tachykinin receptor signaling pathway , heart development , aging , blood circulation , regulation of heart contraction , regulation of G-protein coupled receptor protein signaling pathway , negative regulation of signal transduction , response to organic substance , response to inorganic substance , negative regulation of cell communication , response to organic cyclic substance , phosphorylation , peptidyl-serine phosphorylation , peptidyl-threonine phosphorylation , peptidyl-serine modification , peptidyl-threonine modification , adaptation of signaling pathway , positive regulation of catecholamine secretion , response to hydrogen peroxide , regulation of system process , negative regulation of G-protein coupled receptor protein signaling pathway ,negative regulation of heart contraction , negative regulation of muscle contraction , negative regulation of striated muscle contraction , regulation of catecholamine secretion , regulation of secretion , positive regulation of secretion ,positive regulation of transport , negative regulation of multicellular organismal process , regulation of amine transport ,positive regulation of amine transport , heart contraction , cardiac muscle contraction , regulation of cellular localization ,

Cytoplasm . Cell membrane . Cell junction , synapse , postsynapse . Cell junction , synapse , presynapse .