FLT3

Receptor-type tyrosine-protein kinase FLT3 ;
FL cytokine receptor ;
Fetal liver kinase-2 ;
FLK-2 ;
Fms-like tyrosine kinase 3 ;
FLT-3 ;
Stem cell tyrosine kinase 1 ;
STK-1 ;
CD antigen CD135 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,function:Receptor for the FL cytokine. Has a tyrosine-protein kinase activity. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with FIZ1 following ligand activation. ,tissue specificity:Bone marrow cells. ,

cell activation , hemopoietic progenitor cell differentiation , myeloid progenitor cell differentiation , lymphoid progenitor cell differentiation , pro-B cell differentiation , immune system development , leukocyte differentiation , pro-T cell differentiation , negative regulation of immune system process , regulation of leukocyte activation , negative regulation of leukocyte activation , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway ,transmembrane receptor protein tyrosine kinase signaling pathway , positive regulation of cell proliferation , negative regulation of cell proliferation , phosphorylation , hemopoiesis , lymphocyte differentiation , T cell differentiation , T cell activation , regulation of cell proliferation , leukocyte activation , regulation of B cell differentiation , negative regulation of B cell differentiation , negative regulation of cell differentiation , regulation of lymphocyte differentiation , negative regulation of lymphocyte differentiation , lymphocyte activation , protein amino acid autophosphorylation , hemopoietic or lymphoid organ development , regulation of B cell activation , regulation of cell activation , negative regulation of cell activation , negative regulation of B cell activation , regulation of lymphocyte activation , negative regulation of lymphocyte activation ,

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.