Catalog: KA1559C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
Related Products
Primary Antibodies
Dok-1 Rabbit pAb
YT1393
More→
Primary Antibodies
Dok-1 (Phospho Tyr398) Rabbit pAb
YP0523
More→
Primary Antibodies
Dok-1 (Phospho Tyr362) Rabbit pAb
YP0084
More→
ELISA Kits
Total p62 Dok Cell-Based Colorimetric ELISA Kit
KA4212C
More→
ELISA Kits
p62 Dok (Phospho Tyr398) Cell-Based Colorimetric ELISA Kit
KA1559C
More→
ELISA Kits
p62 Dok (Phospho Tyr362) Cell-Based Colorimetric ELISA Kit
KA1558C
More→
Antigen&Target Information
Gene Name:
DOK1
show all
Other Name:
Docking protein 1 ;
Downstream of tyrosine kinase 1 ;
p62 ;
dok ;
pp62 ;
Downstream of tyrosine kinase 1 ;
p62 ;
dok ;
pp62 ;
show all
Database Link:
Background:
domain:The PTB domain mediates receptor interaction. ,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. ,PTM:Constitutively tyrosine-phosphorylated. ,PTM:Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. ,similarity:Belongs to the DOK family. Type A subfamily. ,similarity:Contains 1 IRS-type PTB domain. ,similarity:Contains 1 PH domain. ,subunit:Interacts with ABL (By similarity) . Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. ,tissue specificity:Expressed in pancreas , heart , leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. ,
show all
Function:
cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , small GTPase mediated signal transduction , Ras protein signal transduction ,
show all
Cellular Localization:
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm , perinuclear region.
show all
Reference Citation({{totalcount}})
Catalog: KA1559C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}