ESR1

Estrogen receptor ;
ER ;
ER-alpha ;
Estradiol receptor ;
Nuclear receptor subfamily 3 group A member 1 ;

domain:Composed of three domains: a modulating N-terminal domain , a DNA-binding domain and a C-terminal steroid-binding domain. ,function:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. ,online information:Estrogen receptor entry ,polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD) . Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density , disrutption of bone microarchitecture , and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture. ,PTM:Glycosylated; contains N-acetylglucosamine , probably O-linked. ,PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity. ,similarity:Belongs to the nuclear hormone receptor family. ,similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily. ,similarity:Contains 1 nuclear receptor DNA-binding domain. ,subunit:Interacts with SLC30A9 (By similarity) . Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3 , NCOA5 and NCOA6 coactivators , leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2 , PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2 , FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. ,

transcription , transcription , DNA-dependent , regulation of transcription , DNA-dependent , anti-apoptosis , intracellular signaling cascade , response to endogenous stimulus , response to hormone stimulus , positive regulation of signal transduction , response to organic substance , positive regulation of macromolecule metabolic process , positive regulation of gene expression , positive regulation of cell communication , regulation of cell death , steroid hormone receptor signaling pathway , estrogen receptor signaling pathway , intracellular receptor-mediated signaling pathway ,RNA biosynthetic process , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , regulation of neuron apoptosis , neuroprotection , response to estrogen stimulus , regulation of transcription , regulation of survival gene product expression , positive regulation of survival gene product expression , regulation of retinoic acid receptor signaling pathway , positive regulation of retinoic acid receptor signaling pathway , response to steroid hormone stimulus , regulation of RNA metabolic process , negative regulation of cell death ,

[Isoform 1]: Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . A minor fraction is associated with the inner membrane.; [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Associated with the inner membrane via palmitoylation (Probable) . At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. .; Nucleus. Golgi apparatus. Cell membrane. Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.