AURKA

Aurora kinase A ;
Aurora 2 ;
Aurora/IPL1-related kinase 1 ;
ARK-1 ;
Aurora-related kinase 1 ;
hARK1 ;
Breast tumor-amplified kinase ;
Serine/threonine-protein kinase 15 ;
Serine/threonine-protein kinase 6 ;
Serine/threonine-protein kinase aurora-A ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,caution:Although authors have considered STK6 and STK15 as two different proteins , it is clear that they are the same protein. ,disease:Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy. ,function:May play a role in cell cycle regulation during anaphase and/or telophase , in relation to the function of the centrosome/spindle pole region during chromosome segregation. May be involved in microtubule formation and/or stabilization. Phosphorylates ARHGEF2 and BORA. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Localizes on centrosomes in interphase cells and at each spindle pole in mitosis. ,subunit:Interacts with TACC1 and CPEB1. Interacts with its substrates BORA and ARHGEF2. ,tissue specificity:Highly expressed in testis and weakly in skeletal muscle , thymus and spleen. Also highly expressed in colon , ovarian , prostate , neuroblastoma , breast and cervical cancer cell lines. Expression is cell-cycle regulated , low in G1/S , accumulates during G2/M , and decreases rapidly after. ,

M phase of mitotic cell cycle , microtubule cytoskeleton organization , mitotic cell cycle , M phase , nuclear division , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cytoskeleton organization ,microtubule-based process , cell cycle , spindle organization , mitosis , intracellular signaling cascade , response to endogenous stimulus , response to hormone stimulus , response to organic substance , posttranscriptional regulation of gene expression , phosphorylation , second-messenger-mediated signaling , cell cycle process , cell cycle phase ,regulation of protein stability , response to estradiol stimulus , response to estrogen stimulus , phosphoinositide-mediated signaling , organelle fission , response to steroid hormone stimulus ,

Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Cytoplasm , cytoskeleton , spindle pole . Cytoplasm , cytoskeleton , cilium basal body . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome , centriole . Cell projection , neuron projection . Detected at the neurite hillock in developing neurons (By similarity) . Localizes at the centrosome in mitotic cells from early prophase until telophase , but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188 , PubMed:17229885 , PubMed:21225229) . Colocalized with SIRT2 at centrosome (PubMed:22014574) . Moves to the midbody during both telophase and cytokinesis (PubMed:17726514) . Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574) . The localization to the spindle poles is regulated by AAAS (PubMed:26246606) . .