Catalog: KA1267C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Main Information
Target
PRAS40 Phospho Thr246
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
Related Products
Primary Antibodies
PRAS40 Rabbit pAb
YT3850
More→
Primary Antibodies
PRAS40 (Phospho Thr246) Rabbit pAb
YP0302
More→
ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
More→
ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
KA1267C
More→
Antigen&Target Information
Gene Name:
AKT1S1 PRAS40
show all
Protein Name:
Proline-rich AKT1 substrate 1;40 kDa proline-rich AKT substrate;
show all
Other Name:
AKT1S1 ;
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
show all
Background:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH , MIM 113508) when phosphorylated (Kovacina et al. , 2003 [PubMed 12524439]) .[supplied by OMIM , Mar 2008] ,
show all
Function:
Function:May play an important role in phosphatidylinositol 3-kinase (PI3K) -AKT1 survival signaling. Substrate for AKT1 phosphorylation , but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection. ,subcellular location:Found in the cytosolic fraction of the brain. ,subunit:The phosphorylated form interacts with 14-3-3. ,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293) . ,
show all
Cellular Localization:
Cytoplasm > cytosol. Found in the cytosolic fraction of the brain.
show all
Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Reference Citation({{totalcount}})
Catalog: KA1267C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}