XRCC5

X-ray repair cross-complementing protein 5 ;
86 kDa subunit of Ku antigen ;
ATP-dependent DNA helicase 2 subunit 2 ;
ATP-dependent DNA helicase II 80 kDa subunit ;
CTC box-binding factor 85 kDa subunit ;
CTC85 ;
CTCBF ;
DNA repair protein XRCC5 ;
Ku80 ;
Ku86 ;
Lupus Ku autoantigen protein p86 ;
Nuclear factor IV ;
Thyroid-lupus autoantigen ;
TLAA ;
X-ray repair complementing defective repair in Chinese hamster cells 5 ;
double-strand-break rejoining ;

developmental stage:Expression increases during promyelocyte differentiation. ,disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86. ,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage. ,function:Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination. The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The Ku p70/p86 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NARG1 , the Ku p70/p86 dimer binds to the osteocalcin promoter and activates osteocalcin expression. ,induction:In osteoblasts , by FGF2. ,PTM:Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity. ,PTM:Sumoylated. ,similarity:Belongs to the ku80 family. ,similarity:Contains 1 Ku domain. ,subunit:Heterodimer of a 70 kDa and a 80 kDa subunit. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK , and with the LIG4-XRCC4 complex. The dimer also associates with NARG1 , and this complex displays DNA binding activity towards the osteocalcin FGF response element (OCFRE) . In addition , the 80 kDa subunit binds to the osteoblast-specific transcription factors MSX2 and RUNX2. Interacts with ELF3. May interact with APLF. ,

telomere maintenance , non-recombinational repair , immune system development , DNA metabolic process , DNA repair ,double-strand break repair , double-strand break repair via nonhomologous end joining , DNA recombination , response to DNA damage stimulus , cell proliferation , positive regulation of cell development , regulation of cell death , DNA integration , viral reproduction , provirus integration , viral infectious cycle , initiation of viral infection , viral reproductive process , lysogeny , hemopoiesis , telomere organization , cellular response to stress , homeostatic process , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of cell differentiation , hemopoietic or lymphoid organ development , stem cell differentiation , regulation of neurogenesis , positive regulation of neurogenesis , positive regulation of developmental process , chromosome organization , regulation of nervous system development , hemopoietic stem cell differentiation ,anatomical structure homeostasis , regulation of cell development , negative regulation of cell death ,

Nucleus . Nucleus , nucleolus . Chromosome .