Catalog: KA1256C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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YP0602
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ELISA Kits
Total HSL Cell-Based Colorimetric ELISA Kit
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ELISA Kits
HSL (Phospho Ser552) Cell-Based Colorimetric ELISA Kit
KA1256C
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ELISA Kits
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Antigen&Target Information
Gene Name:
LIPE
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Other Name:
Hormone-sensitive lipase ;
HSL ;
HSL ;
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Database Link:
Background:
catalytic activity:Diacylglycerol + H (2) O = monoacylglycerol + a carboxylate. ,catalytic activity:Monoacylglycerol + H (2) O = glycerol + a carboxylate. ,catalytic activity:Triacylglycerol + H (2) O = diacylglycerol + a carboxylate. ,enzyme regulation:Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. ,function:In adipose tissue and heart , it primarily hydrolyzes stored triglycerides to free fatty acids , while in steroidogenic tissues , it principally converts cholesteryl esters to free cholesterol for steroid hormone production. ,pathway:Glycerolipid metabolism; triacylglycerol degradation. ,similarity:Belongs to the 'GDXG' lipolytic enzyme family. ,subcellular location:Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. ,subunit:Interacts with PTRF in the adipocyte cytoplasm. ,
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Function:
protein amino acid phosphorylation , neutral lipid metabolic process , acylglycerol metabolic process , triglyceride metabolic process , glycerol ether metabolic process , phosphorus metabolic process , phosphate metabolic process ,female pregnancy , steroid metabolic process , cholesterol metabolic process , lipid catabolic process , sterol metabolic process , phosphorylation , organic ether metabolic process , triglyceride catabolic process , response to drug , cellular lipid catabolic process , glycerol ether catabolic process , diacylglycerol metabolic process , diacylglycerol catabolic process , neutral lipid catabolic process , acylglycerol catabolic process , glycerolipid metabolic process , glycerolipid catabolic process ,
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Cellular Localization:
Cell membrane . Membrane , caveola . Cytoplasm , cytosol . Lipid droplet . Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959) . Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity) . .
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Tissue Expression:
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Signaling Pathway
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
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Catalog: KA1256C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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