Catalog: KA1248C
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96well
$470.00
2 weeks
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
FADD
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Other Name:
Protein FADD ;
FAS-associated death domain protein ;
FAS-associating death domain-containing protein ;
Growth-inhibiting gene 3 protein ;
Mediator of receptor induced toxicity ;
FAS-associated death domain protein ;
FAS-associating death domain-containing protein ;
Growth-inhibiting gene 3 protein ;
Mediator of receptor induced toxicity ;
show all
Background:
domain:Contains a death domain involved in the binding of the corresponding domain within Fas receptor. ,function:Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. ,PTM:Phosphorylated. ,similarity:Contains 1 death domain. ,similarity:Contains 1 DED (death effector) domain. ,subunit:Interacts with CFLAR , PEA15 and MBD4. When phosphorylated , part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. ,tissue specificity:Expressed in a wide variety of tissues , except for peripheral blood mononuclear leukocytes. ,
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Function:
protein complex assembly , apoptosis , induction of apoptosis , cell death , induction of apoptosis by extracellular signals ,activation of pro-apoptotic gene products , positive regulation of signal transduction , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade , macromolecular complex subunit organization , protein oligomerization , protein heterooligomerization ,macromolecular complex assembly , necrotic cell death , protein complex biogenesis ,
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Tissue Expression:
Signaling Pathway
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Apoptosis - multiple species
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway
Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Organismal Systems >> Immune system >> IL-17 signaling pathway
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
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Catalog: KA1248C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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