Catalog: YD2271
Size
Price
Status
Qty.
1mg
$2,820.00
3 weeks
0
100μg
$470.00
3 weeks
0
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Collected
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Detailed Information
Recommended Dilution Ratio
Reconstitute in sterile water for a stock solution
Formulation
Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.
Source
E.coli
Purity
>90% as determined by SDS-PAGE
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Antigen&Target Information
Sequence:
A DNA sequence encoding the human FGF1(Phe16~Asp155) was fused with the C-terminal His Tag
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Other Name:
FGFA,aFGF,ECGF,HBGF-1
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Cellular Localization:
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. .
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Tissue Expression:
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
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Signaling Pathway
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Melanoma
Human Diseases >> Cancer: specific types >> Breast cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Reference Citation({{totalcount}})
Catalog: YD2271
Size
Price
Status
Qty.
1mg
$2,820.00
3 weeks
0
100μg
$470.00
3 weeks
0
Add to cart
Collected
Collect
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