Catalog: KA1228C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Collected
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
VAV
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Other Name:
Proto-oncogene vav
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Background:
domain:The DH domain is involved in interaction with CCPG1. ,function:Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases , thus leading to cell differentiation and/or proliferation. ,miscellaneous:'Vav' stands for the sixth letter of the Hebrew alphabet. ,PTM:Phosphorylated on tyrosine residues. ,similarity:Contains 1 CH (calponin-homology) domain. ,similarity:Contains 1 DH (DBL-homology) domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 phorbol-ester/DAG-type zinc finger. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 2 SH3 domains. ,subunit:May interact with CCPG1 (By similarity) . Interacts with APS , DOCK2 , GRB2 , GRB3 , DOCK2 , SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK , PLCG1 , GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK. ,tissue specificity:Widely expressed in hematopoietic cells but not in other cell types. ,
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Function:
cell activation , endocytosis , phagocytosis , apoptosis , induction of apoptosis , immune response , cell surface receptor linked signal transduction , integrin-mediated signaling pathway , intracellular signaling cascade , cell death , induction of apoptosis by extracellular signals , membrane invagination , regulation of cell death , positive regulation of cell death ,programmed cell death , induction of programmed cell death , membrane organization , vesicle-mediated transport ,death , regulation of cell adhesion , regulation of Rho protein signal transduction , T cell activation , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of GTPase activity , leukocyte activation , positive regulation of cell adhesion , regulation of Ras protein signal transduction , lymphocyte activation , regulation of small GTPase mediated signal transduction , regulation of hydrolase activity ,
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Tissue Expression:
Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> B cell receptor signaling pathway
Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway
Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis
Organismal Systems >> Immune system >> Leukocyte transendothelial migration
Organismal Systems >> Immune system >> Chemokine signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
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Catalog: KA1228C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
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