WNK1

WNK1 ;
HSN2 ;
KDP ;
KIAA0344 ;
PRKWNK1 ;
Serine/threonine-protein kinase WNK1 ;
Erythrocyte 65 kDa protein ;
p65 ;
Kinase deficient protein ;
Protein kinase lysine-deficient 1 ;
Protein kinase with no lysine 1 ;
hWNK1

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,caution:Cys-250 is present instead of the conserved Lys which is expected to be an active site residue. Lys-233 appears to fulfill the required catalytic function. ,caution:PubMed:2507249 describes a peptide sequence containing a GlcNAc glycosylated Ser in position 164 while it is an Arg residue according to others. ,cofactor:Magnesium. ,disease:Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII) [MIM:145260]. PHAII is an autosomal dominant disease characterized by severe hypertension , hyperkalemia , and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron. ,enzyme regulation:By hypertonicity. Activation requires autophosphorylation of Ser-382. Phosphorylation of Ser-378 also promotes increased activity. ,function:Controls sodium and chloride ion transport by inhibiting the activity of WNK4 , potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter , SLC12A3 , by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. ,PTM:O-glycosylated. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with SYT2. ,tissue specificity:Widely expressed , with highest levels observed in the testis , heart , kidney and skeletal muscle. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , ion transport ,intracellular signaling cascade , protein kinase cascade , phosphorylation ,

Cytoplasm .